Pierre A Coulombe Selected Research

Keratin-17 (Keratin 17)

1/2021	A role for keratin 17 during DNA damage response and tumor initiation.
1/2016	Keratins Are Going Nuclear.
8/2015	Keratin-dependent regulation of Aire and gene expression in skin tumor keratinocytes.
3/2015	Regulation of C-X-C chemokine gene expression by keratin 17 and hnRNP K in skin tumor keratinocytes.
12/2011	Type I keratin 17 protein is phosphorylated on serine 44 by p90 ribosomal protein S6 kinase 1 (RSK1) in a growth- and stress-dependent fashion.
10/2010	Keratin 17 promotes epithelial proliferation and tumor growth by polarizing the immune response in skin.
5/2006	Keratin 17 modulates hair follicle cycling in a TNFalpha-dependent fashion.
6/2002	Keratin 17 null mice exhibit age- and strain-dependent alopecia.

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Pierre A Coulombe Research Topics

Disease

8	Neoplasms (Cancer) 01/2021 - 10/2010
8	Wounds and Injuries (Trauma) 01/2017 - 05/2002
6	Pachyonychia Congenita (Jadassohn-Lewandowsky Syndrome) 01/2020 - 06/2002
5	Alopecia (Baldness) 01/2017 - 06/2002
4	Epidermolysis Bullosa Simplex (Epidermolysis Bullosa Herpetiformis Dowling Meara) 03/2017 - 03/2005
4	Inflammation (Inflammations) 01/2017 - 10/2010
3	Palmoplantar Keratoderma (Keratosis Palmaris et Plantaris) 01/2020 - 05/2012
3	Chronic Disease (Chronic Diseases) 01/2018 - 12/2011
2	Rupture 02/2007 - 03/2005
1	Carcinoma (Carcinomatosis) 01/2021
1	Hyperkeratosis of the palms and soles and esophageal papillomas 01/2019
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2017
1	Alopecia Areata 01/2017
1	Inborn Genetic Diseases (Disease, Hereditary) 01/2016
1	Skin Diseases (Skin Disease) 08/2015
1	Carcinogenesis 03/2015
1	Premature Aging 02/2013
1	Cardiomyopathies (Cardiomyopathy) 02/2013
1	Shock 12/2011
1	Psoriasis (Pustulosis Palmaris et Plantaris) 12/2011
1	Hamartoma 10/2010
1	Basal Cell Carcinoma (Rodent Ulcer) 10/2010
1	Hyperalgesia 12/2008
1	Pain (Aches) 12/2008
1	Cysts 09/2008
1	Progeria (Hutchinson Gilford Syndrome) 01/2005
1	Muscular Diseases (Myopathy) 01/2005
1	Neoplasm Metastasis (Metastasis) 11/2004
1	Steatocystoma Multiplex 06/2002
1	Liver Diseases (Liver Disease) 02/2002

Drug/Important Bio-Agent (IBA)

21	Keratins (Keratin)IBA 01/2020 - 02/2002
11	Proteins (Proteins, Gene)FDA Link 01/2021 - 02/2003
8	Keratin-17 (Keratin 17)IBA 01/2021 - 06/2002
3	Keratin-16 (Keratin 16)IBA 01/2019 - 11/2002
3	Type II Keratins (Type II Keratin)IBA 11/2013 - 02/2003
3	Type I Keratins (Type I Keratin)IBA 11/2013 - 02/2003
2	sulforaphaneIBA 03/2017 - 09/2007
2	Intermediate Filament ProteinsIBA 02/2013 - 11/2012
2	Keratin-5 (Keratin 5)IBA 10/2010 - 03/2005
2	Keratin-6 (Keratin 6A)IBA 09/2008 - 10/2003
1	ChromatinIBA 01/2021
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2017
1	AIRE ProteinIBA 08/2015
1	CXC ChemokinesIBA 03/2015
1	RNA-Binding Proteins (RNA-Binding Protein)IBA 03/2015
1	LigandsIBA 03/2015
1	Phosphotransferases (Kinase)IBA 03/2015
1	Heterogeneous-Nuclear Ribonucleoprotein KIBA 03/2015
1	src-Family KinasesIBA 04/2012
1	ErbB Receptors (EGF Receptor)IBA 03/2012
1	Sorbitol (Yal)FDA Link 12/2011
1	Serine (L-Serine)FDA Link 12/2011
1	Phorbol EstersIBA 12/2011
1	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 12/2011
1	Epidermal Growth Factor (EGF)IBA 12/2011
1	Acetates (Acetic Acid Esters)FDA Link 12/2011
1	CytokinesIBA 10/2010
1	Cyclooxygenase InhibitorsIBA 12/2008
1	Ion Channels (Ion Channel)IBA 12/2008
1	Ibuprofen (Motrin)FDA LinkGeneric 12/2008
1	Prostaglandins EIBA 12/2008
1	Dinoprostone (PGE2)FDA Link 12/2008
1	Protein Isoforms (Isoforms)IBA 09/2008
1	Keratin-14 (Keratin 14)IBA 03/2005
1	Microfilament Proteins (Actin Binding Proteins)IBA 11/2004
1	ElementsIBA 05/2002

Therapy/Procedure

1	Hair Removal (Depilation) 01/2017
1	Drug Therapy (Chemotherapy) 01/2017